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17/08/2017 Sovicell recruiting application scientist. 22/03/20173B Pharmaceuticals and Sovicell introduce a novel service offering for plasma protein binding analysis

Science & Technology

TRANSIL Technology Overview

Sovicell’s proprietry TRANSIL technology is both patented and trademarked. Its name is derived from transition silica and refers to proprietary surface modified porous silica beads which serve as a carrier material for biological molecules or structures such proteins, enzymes and membranes.

For protein binding application our chemists prime the bead surface so that it can covalently bind proteins. The resulting protein-coated beads have very little exposed silica surface which practically eliminates any contact of the silica with the solution and keeps unspecific binding of drug candidates or other test substances minimal.

For membrane permeability applications the beads have lipid bilayer membranes attached via non-covalent interactions. This mimics the fluidity of native membranes, and allows the complete range of complex interactions that occur between a drug candidate, or other test substance, and the membrane molecules.

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